Explore Method Changes in Seconds with Pro EZLC Method Translator
Switching an LC method to a smaller column format can save time, solvent, and sample, but proper method translation is essential. Restek’s Pro EZLC method translation software makes it easy to test different scenarios from your desk and ensure success in the lab.
Save Time with Single-Step Sample Prep for d- and l-Amphetamines
In many amphetamine methods, samples like urine and oral fluid are prepared using a two-step process: first they are cleaned up using SPE, then they are derivatized to separate the chiral compounds. We’ve improved this workflow using direct derivatization (no SPE). Here’s how we did it.
Evaluation of a High-Throughput LC-MS/MS Analysis of Amphetamines in Urine
In the final installment of this blog series on the development of an achiral separation of chiral amphetamines on a C18 column, we detail the experiments used to evaluate method performance. Results are discussed for linearity, accuracy, precision, selectivity, and specificity.
Improved Screening Method for Acylcarnitines and Amino Acids
This fast, single-step extraction LC-MS/MS assay provides reliable separation of 22 acylcarnitines and 13 amino acids in dried blood spots. With a fast 1.2 min run and no derivatization, this approach offers the speed of flow injection methods with improved sensitivity and specificity.